Characterisation of solid forms

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Solid forms, key for the quality of drugs

Our team can help you plan the analyses, execute them and interpret the results

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The suitability of a compound or of a solid formulation depends on its physical characteristics, such as its crystalline or amorphous nature, its polymorphic identity and the presence of impurities or patented solid forms.

At Enantia we are experts in the analysis and characterisation of the solid state phase of a compound. We can help you not only in the design of the right analyses but also the interpretation of the results to get the maximum information as fast and comprehensively as possible.

To establish the quality of drug products and substances, our services include:

  • Full characterisation of a given solid form
  • Quantification of one crystalline form in another crystalline form
  • Determination of an amorphous content in a crystalline matrix or vice-versa
  • Evaluation of the presence or absence of different crystalline forms in given samples
  • Evaluation of sample thickness
  • Particle size and shape
  • Stability monitoring

Our crystallographic and analytic teams plan the most relevant analyses, execute them and interpret the results for you. Selecting the right techniques and experimental conditions will make sure to obtain the required information at any stage of a project.

Available techniques

  • X-ray powder diffraction (transmission and reflection)
  • Single crystal X-ray diffraction
  • Synchrotron X-ray diffraction (powder and single crystal)
  • FTIR spectroscopy
  • Raman spectroscopy
  • Differential scanning calorimetry (DSC)
  • Thermogravimetric analysis (TGA)
  • Dynamic vapour sorption (DVS)
  • Scanning electron microscopy
  • Transmission electron microscopy (TEM)
  • Optical microscopy
  • Particle size distribution (PSD)
  • Specific surface area analysis (BET) and porosimetry
  • Karl Fischer titration