Equipment

At Enantia, we utilize cutting-edge equipment and techniques to ensure precise analysis, characterization, and optimization of chemical compounds and solid forms. Our state-of-the-art instrumentation and expert team enable us to provide high-quality analytical support and comprehensive solid-state research, tailored to meet the needs of your project.

Analytical equipment at Enantia used for small molecule characterization through HPLC-MS and CG-MS services.
Chromatographic Systems
  • Chiral and achiral: HPLC, UPLC, GC, GPC
  • HPLC-MS, GC-MS, HPLC-MS/MS, HPLC-HRMS
  • Chiral and achiral semi-preparative and preparative HPLC
  • Automated medium pressure liquid chromatography (direct/reverse phase)
Spectroscopic Techniques
  • Spectroscopy: Mass, FTIR, UV, Polarimetry, Raman
  • NMR: from 400 MHz up to 1 GHz
  • Solid-state NMR (ssNMR)
Mass Spectrometry and Elemental Analysis
  • ICP-OES / ICP-MS
  • Elemental analysis
Additional Techniques
  • Karl Fischer titration: Determination of water content
  • Specific rotation ([α]D)
- Flow chemistry equipment at Enantia for CRO services in Drug Discovery and API development.
Reactor Systems
  • Flow chemistry reactors
  • Chemical pressure reactors (0.1–0.5 L)
  • Microwave reactor
  • Kilo Lab (15 L jacketed reactor plus 20 L auxiliary reactor)
  • Dedicated hydrogenation lab
Crystallographic Analysis
  • X-ray powder diffraction (transmission and reflection) (XRPD)
  • Single crystal X-ray diffraction (SCXRD)
  • Synchrotron X-ray diffraction (powder and single crystal)
  • Electron diffraction
Thermal and Structural Analysis
  • Differential scanning calorimetry (DSC)
  • Thermogravimetric analysis (TGA)
  • Dynamic vapour sorption (DVS)
Microscopy and Imaging
  • Scanning electron microscopy (SEM)
  • Transmission electron microscopy (TEM)
  • Optical microscopy (including polarized light)
Surface and Particle Characterization
  • Particle size distribution (PSD)
  • Specific surface area analysis (BET) and porosimetry
Crystalline or amorphous solids from a solid form screening at Enantia in a stability study, placed in a climatic chamber at controlled temperature and relative humidity.
Press equipment for stability testing under pressure, and solubility studies through Intrinsic Dissolution Rate (IDR) using Wood’s apparatus.
Stability testing
  • Stability chambers with controlled temperature and relative humidity conditions
  • Stability under pressure 
  • Stability in solution
  • Light stability
Drying

  • Lyophilizer

  • Spray drier (Büchi Mini Spray Dryer B-290, compatible with aqueous and organic solvents)
Solubility

  • Intrinsic Dissolution Rate (IDR) – Wood’s apparatus