Drug Discovery Services
Advancing Medicinal Chemistry through synthetic expertise
At Enantia, we offer medicinal chemistry solutions designed to accelerate drug discovery and optimize therapeutic outcomes. With expertise in the structure-based drug design and synthesis of small molecules targeting GPCRs, enzymes, ion channels, and nuclear receptors, we provide cutting-edge support for all stages of a drug discovery program.
From initial Hit identification, Hit-to-Lead and Lead Optimization until Candidate selection
- Structure activity relationship (SAR) design and synthesis of libraries of small molecules.
- Rapid modifications driven by biological and ADME studies feedback to enhance potency, selectivity, and drug-like properties.
- Parallel synthesis and automated purification techniques, including preparative HPLC, to enable rapid development of focused libraries of new chemical entities.
- Use of flow chemistry to speed-up the preparation of analogues and reach new chemical reactivity unattainable by conventional batch synthesis.
- Convergent synthesis strategies to introduce diversity points late in the sequence, ensuring streamlined workflows.
Synthesis of cold labelled compounds
- Expertise in designing and synthesizing stable isotope-labeled compounds, including deuterated compounds for analytical and DMPK studies.
- Comprehensive analysis of synthetic routes and labeled starting materials to design the best route to effectively introduce the required isotopes in the desired positions. Design of positions to be labelled on a case-by-case basis.
Impurity and Metabolite Synthesis for toxicological studies
- De novo synthesis of impurities and metabolites for toxicological in vitro and GLP studies.
Scale-Up Activities
- Custom synthesis services up to kilogram scale of key compounds such as leads and candidates, reference compounds, intermediates, and key building-blocks.
- Evolution of the medicinal chemistry synthetic pathway into a scalable route suitable for delivering larger amounts.
Solid form selection
- Initial salt and cocrystal screening to maximize solubility, stability and bioavailability.
- Full solid form screening studies that include salt, cocrystal, polymorph and solvate screenings.
- Solid-state characterization
Equipment
At Enantia, we utilize cutting-edge instrumentation and techniques to ensure precise analysis, characterization, and optimization of chemical compounds and solid forms. Our state-of-the-art facilities and expert team enable us to provide high-quality analytical support and comprehensive solid-state research, tailored to meet the needs of your project.